Serum erythropoietin levels and the effect of administering human recombinant erythropoietin to patients with chronic rejection.

The effect of recombinant human erythropoietin (rHuEpo) on blood cells of adult and immature rats

Human recombinant erythropoietin is a synthetic hormone for treatment of some kinds of anemia. In this study, the effect of this hormone was investigated on blood cell changes in adult and immature rats. For this purpose, the hormone was administered at doses of 50, 100, and 200 IU/Kg (s.c.) twice a week for a period of 6 weeks. Then, the number of red blood cells (RBC), subtypes of white blood...

Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients.

OBJECTIVE The aim of this study was to analyze the factors that are associated with the response to erythropoiesis-stimulating agents (ESAs) and its association with hospitalization and mortality rates; to evaluate the serum hepcidin level and its associations with iron profile, inflammatory markers, ESA responsiveness, and mortality; and to determine independent factors affecting ERI and hepci...

Differences between the N-glycans of human serum erythropoietin and recombinant human erythropoietin.

The differences between the N-glycans of human erythropoietin (hEPO), extracted from serum, and recombinant human erythropoietin (rhEPO) reported by Skibeli et al1 have received attention in the editorials of 2 other journals. One suggested that these differences might be involved in the etiology of the autoimmune pure red cell aplasia found in some patients treated with rhEPO.2 The other sugge...

the impact of human recombinant erythropoietin on renal function in patients with chronic kidney disease

Hyporesponsiveness to recombinant human erythropoietin.

The introduction of recombinant human erythropoietin (rh-Epo, epoetin) as a treatment for the anaemia of renal failure has transformed the management of this condition. Nevertheless, a significant number of patients fail to respond. There are many different possible causes of inadequate response to epoetin. Iron deficiency, whether absolute or functional, is considered to be the most important,...